09 May 2016
Julien Cors and Dr. Govind Kaigala were interviewed for Reuters’ article about the Microfluidic Probe.
01 April 2016
Julien Cors and Dr. Govind Kaigala were interviewed for IBM Reasearch News blog.
Microfluidic Probe for Personalized Healthcare
The sequencing of the entire human genome back in the early 2000s is considered one of the most important scientific breakthrough enabling data-driven medicine.
It flooded researchers in biology with a tremendous amount of Big Data that needed to be processed and tested. It was around then that DNA microarrays, small glass chips where thousands of DNA fragments are deposited, became popular because they enable high-throughput and multiplexed testing for gene expression and mutations, for example in cancer.
Interestingly, DNA and protein microarrays were one of the convergence points of microtechnology and biology that resulted in the fabrication of high-density arrays of biomolecules.
While protein microarrays have significant value for drug discovery, and molecular profiling, the same success in the use of DNA arrays was not transferable to protein arrays due to the limited quality of protein arrays.
This inspired a team of IBM scientists to develop a new biopatterning method for efficient, accurate and high-quality patterning of proteins on surfaces by addressing fundamental bottlenecks inherent to the fabrication of protein microarrays. Such high-quality microarrays will benefit quantitative biological assays for personalized diagnostics and screening applications.
29 March 2014
Dr. Govind Kaigala was interviewed by BBC Arabia during CeBiT 2014 in Hannover. Interview starts at 7 min 55 s
23 October 2013
IBM and University Hospital Zurich work on tissue micro-processing (see article here) within the framework of µfluidix (supported by the Swiss Initiative in Systems Biology, SystemsX.ch) the to advance the microfluidic probe technology in the context of clinically relevant topics.