Nadya Ostromohov received an award for best Oral Presentation at the Batsheva de Rothschild Seminar on New Concepts in Biosensing held in Dead Sea, Israel in February 2017 for her work “Sequential delivery of reagents with minimal dispersion for surface chemistry assays and characterization of biomolecular responses.”
In this talk, Nadya focused on a new method for sequential delivery of reagents to a surface-bound reaction site with minimal dispersion of their interfaces. Sequential delivery of multiple reagents is key in a large number of surface biochemical assays and yet is highly challenging to implement. In this method, segmented flows were used to encapsulate the reagents as droplets, thereby keeping dispersion between reagent plugs confined in a limited volume, and were transmitted to the reaction surface using a custom microfluidic probe head. She demonstrated the measurements of receptor-ligand reaction kinetics and protein response to chemical stimuli. Such a method will be useful for studying the dynamic response of cells and proteins to various stimuli, as well as for highly automated multi-step biological assays.
Nadya also recently reported this work in Lab on a Chip; this article was featured as a cover page.
The Batsheva de Rothschild Seminar are topical conferences attended by a select group of internationally leading scientists.
This work was performed as part of Virtual Vials ITN, a project funded by the EU under the FP7 framework. Nadya is academically affiliated to the Microfluidic Technologies Laboratory of Assistant Professor Moran Bercovici at the Department of Mechanical Engineering, Technion, Israel.