I n line with the atomic force microscope and the scanning probe microscope developed at IBM-Zurich, the microfluidic probe (MFP) was conceived to process and interact with surfaces. The early versions of the MFP demonstrated suitability for working on biological surfaces. A key step in the technology evolution was the transformation of the original format, which was essentially co-planar to scanned surfaces, into a vertical MFP technology. The vertically-oriented MFP, now called the vMFP, is significantly expanding the versatility the probe.
The working principle of the vMFP is described in “A vertical microfluidic probe.”